Dr Xiaotao Jiang
Bachelor of Engineering (Bioinformatics)
Doctor of Philosophy (Water and Environmental Microbiology)
My Current Research Interests:
1. Microbiome in health and diseases
2. Antimicrobial resistance听
3. Virome
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Dr Xiaotao Jiang is a microbiome and antimicrobial resistance researcher at the Microbiome Research Centre, 91色情片 Sydney. He leads the antimicrobial resistance theme at the Centre and serves as the lead bioinformatician, leading a team of bioinformaticians across national and international microbiome collaborations.
Dr Jiang鈥檚 current leading research focuses on precision microbiome therapeutics, particularly AI-supported super donor selection for faecal microbiota transplantation. He leads a NSW Health Early-Mid Career grant as CIA to develop a multi-omics-based donor selection and donor matching platform for obesity and dementia.听 For the MRFF-supported Healthy Optimal Australian Microbiome project, he leads multi-omics analysis to define healthy microbiome states. His donor selection program aims to move FMT from empirical donor screening toward precision microbiome therapeutics.
In antimicrobial resistance, Dr Jiang developed ARGs-OAP, a widely used bioinformatics platform for quantitative resistome profiling from shotgun metagenomic data. His AMR research now extends from surveillance to intervention, including AI-enabled discovery of novel antimicrobial peptides and One Health approaches to AMR monitoring.
Dr Jiang completed his PhD at The University of Hong Kong, where he applied large-scale metagenomic sequencing to study activated sludge microbial ecology across spatial and temporal dimensions. His methodological interests include integrate AI, bioinformatics algorithms and software for next- and third-generation sequencing and multi-omics data, including metagenomics, metatranscriptomics, metabolomics, and host molecular datasets.
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- Publications
- Media
- Grants
- Awards
- Research Activities
- Engagement
- Teaching and Supervision
1. Using state-of-the-art multi-omics to optimise selection of Faecal Microbiota Transplant (FMT) super donors for treatment of obesity and dementia.听NSW Health Early-Middle Career Grant for Microbiomics,听$499,335.20. CIA.听 2023-2026听
2. Defining an antiaging microbiome through the optimal healthy microbiome. Ageing Future Institute seed funding, 25,200 AUD. CIA, 2023听
3.听Defining the role and therapeutic manipulation of the gut-lung axis in respiratory disease. NHMRC Synergy grant, 5M AUD. CII, 2022-2026.听
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Healthy Optimal Australian Microbiome (HOAM)
The Healthy Optimal Australian Microbiome (HOAM) project in the Australian First dedicated Microbiome Research Centre (MRC). This project is supported by Medical Research Future Fund (MRFF).听 This ambitious project aims to hunt the optimal healthy microbiome in the Australian population, which will be a crucial target to manipulate the microbiome to, especially for faecal microbiome transplant (FMT) to cure diseases.听The microbiome plays an important role in human health and has been implicated in the pathogenesis of many diseases. However, the definition of a 鈥渘ormal microbiome鈥 remains elusive. Previous definitions have focussed mainly on microbial taxonomy with less rigour in defining optimal health. We seek to define the healthy microbiome by studying supremely healthy individuals recruited through a stringent matrix and benchmarked against obesity and dementia patients. Meanwhile, we have established a huge publicly available human shotgun metagenomic microbiome data set. This big data will be integrated and compared with our HOAM dataset with an artificial intelligence algorithm to define a healthy microbiome. MRC has established powerful high-performance computing facilities and use national computing infrastructure (NCI) to support the project.听
AI-assised Super donor selection through multi-omics (precision FMT)
I apply healthy microbiome to boost health and do intervention agnist disease through precision fecal microbiota transplant. This project is supported by Dr Jiang Early Middle Career Research Grant听 by NSW Health, from which he will establish a super donor selection platform for FMT intervention in clinical trials for obesity and dementia using the multi-omics data.听听
Novel Antimicrobial Peptides听
Antimicrobial peptides (AMPs) are important but less studied novel antimicrobial, they play important role in shaping the microbiome communities with multi-fact functions beyond antimcrobials like regulate immune system, anticancer effects, et, al. We are working in a program to detect novel AMPs from human microbiome and investigate their role in health and diseases.听听
AussiResistome
This project is to establish the antimicrobial resistome of Australians, and importantly understand the drivers and consequences of elevated resistome on both chronic and acute diseases. The role of human reseistome in health and diseases has been investigated in descriptive studies, however, their roles for human health has not been understand well.听 In this program, we will obtain a full picture of how Aussi' antimicrobial resistome are shaped and impacting the health and diseases of Australians.听听
Advisory topic board member for the journal Antibiotics听
Editor on board of Gut
Member of听Australian bioinformatics and computational society (ABACBS)
Member of Ageing Future Institute
Member of Australian Human Microbiome Research Network
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My Research Supervision
Dr Jiang currently supervise honour student and PhD candidates on human microbiome, antimicrobial resistance and antimicrobial peptides.听
I have supervised 8 honour/ILP students to finish.听
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