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Dr Krystyna Gieniec

Dr Krystyna Gieniec

Lecturer
Medicine & Health
School of Biomedical Sciences

Krystyna's research evolves around the mammary gland, where she hopes to discover how the epithelium and its adjacent stroma interact via calcium-induced signals to promote mammary development at both embryonic and cancerous stages. To study this, Krystyna employs the use of genetically modified animal models and complex 3D cell systems coupled with advanced 3D volumetric microscopy imaging.
E-mail
k.gieniec@unsw.edu.au
Location
Room 317, Level 3, Lowy Building
  • Journal articles | 2022
    Dhakal B; Li CMY; Li R; Yeo K; Wright JA; Gieniec KA; Vrbanac L; Sammour T; Lawrence M; Thomas M; Lewis M; Perry J; Worthley DL; Woods SL; Drew P; Sallustio BC; Smith E; Horowitz JD; Maddern GJ; Licari G; Fenix K, 2022, 'The Antianginal Drug Perhexiline Displays Cytotoxicity against Colorectal Cancer Cells In Vitro: A Potential for Drug Repurposing', Cancers, 14,
    Journal articles | 2022
    Gieniec KA; Davis FM, 2022, 'Mammary basal cells: Stars of the show', Biochimica Et Biophysica Acta Molecular Cell Research, 1869,
    Journal articles | 2022
    Gieniec KA, 2022, 'Mammary gland architecture under the lens: How visualising tissues in 3D provides deeper insights into structure and function', Biochimica et Biophysica Acta - Molecular Cell Research, 1869,
    Journal articles | 2022
    Gieniec KA, 2022, 'Scope for change', Journal of Cell Science, 135,
    Journal articles | 2022
    Kobayashi H; Gieniec KA; Lannagan TRM; Wang T; Asai N; Mizutani Y; Iida T; Ando R; Thomas EM; Sakai A; Suzuki N; Ichinose M; Wright JA; Vrbanac L; Ng JQ; Goyne J; Radford G; Lawrence MJ; Sammour T; Hayakawa Y; Klebe S; Shin AE; Asfaha S; Bettington ML; Rieder F; Arpaia N; Danino T; Butler LM; Burt AD; Leedham SJ; Rustgi AK; Mukherjee S; Takahashi M; Wang TC; Enomoto A; Woods SL; Worthley DL, 2022, 'The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis', Gastroenterology, 162, pp. 890 - 906,
    Journal articles | 2021
    Ichinose M; Suzuki N; Wang T; Kobayashi H; Vrbanac L; Ng JQ; Wright JA; Lannagan TRM; Gieniec KA; Lewis M; Ando R; Enomoto A; Koblar S; Thomas P; Worthley DL; Woods SL, 2021, 'The BMP antagonist gremlin 1 contributes to the development of cortical excitatory neurons, motor balance and fear responses', Development Cambridge, 148,
    Journal articles | 2021
    Ichinose M; Suzuki N; Wang T; Wright JA; Lannagan TRM; Vrbanac L; Kobayashi H; Gieniec K; Ng JQ; Ihara S; Mavrangelos C; Hayakawa Y; Hughes P; Worthley DL; Woods SL, 2021, 'Delineating proinflammatory microenvironmental signals by ex vivo modeling of the immature intestinal stroma', Scientific Reports, 11,
    Journal articles | 2021
    Ichinose M; Suzuki N; Wang T; Wright JA; Lannagan TRM; Vrbanac L; Kobayashi H; Gieniec KA; Ng JQ; Hayakawa Y; García-Gallastegui P; Monsalve EM; Bauer SR; Laborda J; García-Ramírez JJ; Ibarretxe G; Worthley DL; Woods SL, 2021, 'Stromal DLK1 promotes proliferation and inhibits differentiation of the intestinal epithelium during development', American Journal of Physiology Gastrointestinal and Liver Physiology, 320, pp. G506 - G520,
    Journal articles | 2021
    Kobayashi H; Gieniec KA; Ng JQ; Goyne J; Lannagan TRM; Thomas EM; Radford G; Wang T; Suzuki N; Ichinose M; Wright JA; Vrbanac L; Burt AD; Takahashi M; Enomoto A; Worthley DL; Woods SL, 2021, 'Portal vein injection of colorectal cancer organoids to study the liver metastasis stroma', Journal of Visualized Experiments, 2021,
    Journal articles | 2021
    Kobayashi H; Gieniec KA; Wright JA; Wang T; Asai N; Mizutani Y; Lida T; Ando R; Suzuki N; Lannagan TRM; Ng JQ; Hara A; Shiraki Y; Mii S; Ichinose M; Vrbanac L; Lawrence MJ; Sammour T; Uehara K; Davies G; Lisowski L; Alexander IE; Hayakawa Y; Butler LM; Zannettino ACW; Din MO; Hasty J; Burt AD; Leedham SJ; Rustgi AK; Mukherjee S; Wang TC; Enomoto A; Takahashi M; Worthley DL; Woods SL, 2021, 'The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis', Gastroenterology, 160, pp. 1224 - 1239.e30,
    Journal articles | 2019
    Gieniec KA; Butler LM; Worthley DL; Woods SL, 2019, 'Cancer-associated fibroblasts—heroes or villains?', British Journal of Cancer, 121, pp. 293 - 302,
    Journal articles | 2019
    Lannagan TRM; Lee YK; Wang T; Roper J; Bettington ML; Fennell L; Vrbanac L; Jonavicius L; Somashekar R; Gieniec K; Yang M; Ng JQ; Suzuki N; Ichinose M; Wright JA; Kobayashi H; Putoczki TL; Hayakawa Y; Leedham SJ; Abud HE; Yilmaz ÖH; Marker J; Klebe S; Wirapati P; Mukherjee S; Tejpar S; Leggett BA; Whitehall VLJ; Worthley DL; Woods SL, 2019, 'Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis', Gut, 68, pp. 684 - 692,
    Journal articles | 2017
    Boyle ST; Gieniec KA; Gregor CE; Faulkner JW; McColl SR; Kochetkova M, 2017, 'Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells', Molecular Cancer, 16,
  • Other | 2022
    Gieniec K, 2022, Scope for Change,
    Preprints |
    Ahmed IA; Liu J-J; Gieniec KA; Bair-Marshall CJ; Adewakun AB; Hetzler BE; Arp CJ; Khatri L; Vanwalleghem GC; Seidenberg AT; Cowin P; Trauner D; Chao MV; Davis FM; Tsien RW; Froemke RC, Optopharmacological tools for precise spatiotemporal control of oxytocin signaling in the central nervous system and periphery,
    Preprints |
    Chalmers SB; Stewart TA; Hughes K; Kurumlian A; Folacci M; Gieniec KA; Stevenson AJ; Teakle N; Sehgal A; Paydari E; Thomsen JS; Irvine KM; Pandzic E; Poole K; Hume DA; Davis FM, Macrophage calcium signaling dynamics revealed using genetically-encoded sensors,

2023-2028: NHMRC Emerging Leadership Level 1 Investigator Grant [CIA]

2023-2025 (declined): Cancer Institute NSW Early Career Fellowship [CIA]

2025:Ìý'The Illuminators' virtual microscopy exhibition for 91É«ÇéƬ Diversity Fest 2025 (The Illuminators: Scope for Change | Equity, Diversity & Inclusion - 91É«ÇéƬ Sydney) [CI]

2023: 91É«ÇéƬ Cancer Theme EMCR Seed Grant [CIB]

2023:Ìý'The Illuminators' virtual microscopy exhibition for 91É«ÇéƬ Diversity Fest 2023 (The Illuminators: Scope for Change | Equity, Diversity & Inclusion - 91É«ÇéƬ Sydney) [CI]

2021:Ìý'The Illuminators' virtual microscopy exhibition for 91É«ÇéƬ Diversity Fest 2021 (The Illuminators: Scope for Change | Equity, Diversity & Inclusion - 91É«ÇéƬ Sydney) [CIA]

2025
- Best Image Award for the 2025 ANZSCDB NSW Symposium
- Nominated for 91É«ÇéƬ Vice-Chancellor’s Awards for Values in Action - Builds Collaboration
- Nominated for 91É«ÇéƬ Faculty of Medicine and Health Values in Action - Diversity Award (team)

2023
- Nikon Award for best 10-minute oral presentation (SBMS Research Symposium)
- 91É«ÇéƬ Faculty of Medicine and Health Values in Action - Diversity Award (team)

2022
- Cover image for BBA Molecular Cell Research
- Postdoctoral Travel Award (SBMS, 91É«ÇéƬ)
- Travel Fellowship Award for Junior Researchers (European Calcium Society)
- Drabikowski Award for best talk by an early career researcher and for showing promise as an emerging leader (16th International Meeting of the European Calcium Society)
- 91É«ÇéƬ SBMS Young Researcher of the Year Award

2021
- Dean's Commendation for Doctoral Thesis Excellence
- People’s Choice Award for Favourite Video in ‘The Illuminators’ microscopy exhibition (as part of Diversity Fest 2021; The Illuminators: Scope for Change | Equity Diversity & Inclusion - 91É«ÇéƬ Sydney)
- First place in the Live Cell Imaging Category of the LMA/VIA 2021 Image Competition ()
- Best Image Award for the 2021 ANZSCDB microscopy imaging competition ()

2017-2020
- Lions Medical Research Foundation Inc Supplementary Scholarship
- Research Training Program Stipend

2020
- Basic Science Young Investigator Award finalist (GESA Annual Scientific Meeting)

2019
- Merck Business and Enterprise Prize (13th Annual Florey Postgraduate Conference)

2018
- Adelaide Graduate Centre Research Travel Scholarship

2016
- Jemima Lendrum Honours Grant
- Gastrointestinal Cancer Biology Group Honours Scholarship

2014
- Summer Research Scholarship

My Research Supervision

2025 - onwards
- PhD candidate Macrina Milani Capialbi (Aarhus University, co-supervisor)

2026
- Honours student Ishita Tayal (91É«ÇéƬ, primary supervisor)
- Honours student Narjis Badami (91É«ÇéƬ, co-supervisor)

2024
- Honours student Maliha Aynn Aslam Dossani (91É«ÇéƬ, primary supervisor, First Class)
- Honours student Haoyi Han (91É«ÇéƬ, co-supervisor, First-Class)

2022
- Honours student Oscar Chen (91É«ÇéƬ, co-supervisor, Second Class)