Associate Professor Kate Michie
Education
- BSc Hons (1st Class) (The University of Sydney). 1998
- PhD (The University听of Sydney) 2004
Biography
Associate Professor听 is Chief Scientist of the 听Structural Biology Facility (MWAC) and an academic in BABS. She is听a molecular biologist/biochemist with special interests in structural biology. While she is a fully trained macromolecular X-ray crystallographer, she currently leads a specialist compute team supporting AI/Deep Learning methods for 91色情片 researchers in structural biology.听
Kate completed her doctoral degree at the under the supervision of Dr Liz Harry and Professor Gerry Wake, working in the field of bacterial cell division. (For work completed during this time see and ).
In 2005 she received a L'Or茅al-UNESCO Fellowship and spent the next five years working with at the in Cambridge, UK. She carried out research into the structure and function of Structural Maintenance of Chromosome (SMC) complexes and how they exert molecular control over the topological and spatial organization of chromosomes (see ). In 2006 she received a Marie Curie Incoming Postdoctoral Fellowship and continued working on SMC proteins and within the bacterial cell division field. During this time in Cambridge she published a number first author papers (including , , and ) and contributed significantly to work published in and .
She returned to science in Australia in 2012, working with and at the University of Sydney. In this role she worked on Myosin Binding protein C (see and ).
In 2015 Kate joined 91色情片 as a Senior Research Associate working with working on light harvesting proteins (see ) and the Ezrin family of proteins ( see and )
In 2019 Kate established the Structural Biology Facility (SBF) with at 91色情片 ().
听
Professional Experience
Associate Professor &听Chief Scientist SBF, MWAC 91色情片
Senior Research Associate, School of Physics, 91色情片. (2015-2019)
Senior Postdoctoral Scientist, School of Molecular Biosciences, The University of Sydney (2012-2015)
MRC Investigator Scientist, MRC Laboratory of Molecular Biology, Cambridge, UK.(2008-2010)
Marie Curie International Fellow, MRC Laboratory of Molecular Biology, Cambridge, UK. Funded by 6th European Commission Framework (2006-2008)
UNESCO L'OREAL International Fellow for Young Women in Life Sciences MRC Laboratory of Molecular Biology, Cambridge. Supervisor鈥揇r Jan L枚we. Funded by UNESCO and L鈥橭real. (2005)
Postdoctoral Scientist, School of Molecular and Microbial Biosciences, The University of Sydney, Australia. Supervisor鈥Dr Liz Harry and Professor Gerry Wake. (2004)
听
Professional Activities
听
- Chairman of the Sydney Protein Group (Nov 2021-2024)
- Greater Sydney CAP Leader for Synchrotron beam time at the Australian Synchrotron (Sept 2021- current).
- Established 91色情片 Structural Biology Facility. This includes a number of biophysical analysis instruments, a number of robotic liquid handlers and an X-ray diffractometer since 2019
- NSW Cryo EM Users Group Meeting co-organiser听 and Chair (with Dr Nick Ariotti) 听G37, F10 Chemical Sciences Building, 91色情片, 听 听 Thursday 28th February 2019.
- Interactive Science Expo Session presenter, 91色情片, November 28th 2019, Wallace Wurth Building听
- Structural Biology Session organizer and presenter, Sensory Scientific Exhibition & Discovery Day, 91色情片, December 11th 2018, Wallace Wurth Building
- Invited Chair for Integrative Structural Biology Symposium, Combio 2018, Sydney
- Organizational Committee member, Australian Society of Biophysics Meeting, UTS.
- Organiser and chair of Cryo EM Australian Society of Biophysics Workshop, UTS, 2017
- NSW ASBMB State Representative (Australian Society of Biochemistry and Molecular Biology) (2015-2017)
听
- Publications
- Media
- Grants
- Awards
- Research Activities
- Engagement
- Teaching and Supervision
听
National
Targeting the TOPORS E3 Ubiquitin Ligase to Overcome Resistance to Hypomethylating Therapy in Acute Myeloid Leukemia / Cancer Council NSW/Research Project Grants(**) / $600,000. Prof John Pimanda (Lead), Dr Chris Jolly, Dr Ernest Moles Meler & A/Prof Kate Michie
听
听
Establishment of a comprehensive rhabdomyolysis genetic diagnostic pipeline - a large cross-disciplinary Australian collaboration / National Health & Medical Research Council/MRFF - Genomics Health Futures Mission (MRFF)(**) / $2,910,959. A/Prof Emily Oates (Lead), Prof Marc Wilkins, Prof Paul Curmi, A/Prof Kate Michie, Prof Michelle Farrar & Andrei Smolnikov (Admin Contact Networks)
Advancing congenital and childhood-onset muscle disease diagnosis and treatment - a cross-disciplinary Australian collaboration / National Health & Medical Research Council/EPCDRI - Chronic Musculoskeletal Conditions in Children and Adolescents (MRFF)(**) / $2,499,988. A/Prof Emily Oates (Lead), Prof Kate Quinlan, Prof Marc Wilkins, Prof Paul Curmi & A/Prof Kate Michie
2025-2027 BioCommons Australia Project / University of New South Wales/Australian BioCommons , A/Prof Kate Michie (Lead)
Institutional
2025-2027 91色情片 3Rs Grant 鈥 Associate Professor Katharine Michie (SBF) Associate Professor Jai Tree (BABS), Dr Thomas Litfin (SBF)Title: 鈥淒e novo Protein Binder Design and Validation as an Alternative to Animal-derived Antibodies鈥 Funding: $75,000
听
听
International
ASIAN OFFICE OF AEROSPACE R&D 21IOA019.听Awarded Sep 2021 for funding 2021-2023.
听
2026- Sparrow Award for Lorne Proteins 2026 Conference. Best abstract (awarded a talk) for established researcher. Lorne Victoria
2025 Australian Society for Biophysics People鈥檚 Choice: Best established Researcher Talk 2025
2025 91色情片 Vice Chancellors Award for Collaboration
2024听PVCRI Innovation Award (91色情片)听
2007 听 听Named 鈥楻ising Talent鈥 and short-listed for Women鈥檚 Forum 3rd Ed, Deauville, France.
2006 听 听Marie Curie International Fellowship Funded by 6th European Commission Framework
2005听听听UNESCO L'Oreal International Fellowship for Women in Science 7th edition of the L鈥橭R脡AL-UNESCO FOR WOMEN IN SCIENCE (Life sciences), Funded by UNESCO and L鈥橭real.
We want to understand how biology uses proteins to control the shape of membranes. In particular we focus on the proteins essential to the processes of cell division and building cell surface structures such as villi and vesicles. The proteins involved in these processes interact with themselves and with the membrane to bend and shape it, and to tether other proteins to it. The types of proteins involved arise in all the domains of life鈥 archaea, bacteria and eukaryotes, and, maybe not surprisingly, are often carried out by related proteins.
We focus on understanding structurally the proteins that carry out these tasks. We use X-ray crystallography, cryo-electron microscopy and a range of protein and biophysical experiments to probe our targets.
听
CURRENT RESEARCH ACTIVITIES
-
Dynamin-like Proteins in Bacteria
-
Tubulin-like proteins in Bacteria and Archaea (collaboration with Dr Brendan Burns)
-
Ezrin/Moesin and Merlin and the membrane in humans (Jointly supervised with Prof Curmi)
-
Understanding mutations in clinical setting (collaboration with Dr Emily Oates)
-
Alphafold2- implementation and it's roles in听integrative听structural biology
听
My Research Supervision
PhDs in Physics
PhDs in BABS
Honours in BABS
My Teaching
Currently teaching into: