Dr Gregory Redpath

Back to

Dr Gregory Redpath

Lecturer

Ph.D. Medicine听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听 Feb 2011- Aug 2015

Department of Child and Adolescent Health, University of Sydney, Sydney, Australia

B.Sc. (Hons.) Biochemistry听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听Feb 2007- Dec 2010

Department of Biochemistry, University of Otago, Dunedin, New Zealand

Medicine & Health

School of Biomedical Sciences

Dr Gregory Redpath is an Associate Group Leader in the Department of Molecular Medicine in the School of Biomedical Sciences. His research focusses on the cell biology of receptor trafficking and its role in serotonin receptor signalling in cardiovascular disease, depression, and anxiety. Dr Redpath undertook his Bachelor of Science (Honours) in the Department of Biochemistry, University of Otago (2007-2010), and PhD at the University of Sydney (2011-2016). Following, he has undertaken postdoctoral position at the University of New South Wales and University of Otago, building a track record in developing advanced live cell imaging techniques to dissect the mechanisms of how cellular processes underpin our health. Dr Redpath's current research aims to uncover how psychedelics act at the molecular level to lead to better treatments for depression and anxiety, identifying the therapeutic potential of psilocybin-related compounds sourced from mushrooms, investigating how serotonin signalling intersects with development of cardiovascular disease, and to work in consultation with First Nations communities to integrate culturally guided molecular research to generate meaningful data and outcomes for these communities.

E-mail

g.redpath@unsw.edu.au

Journal articles | 2025

Deo N; Siddiqui H; Peppercorn K; Madani G; Rutherford-Blyth A; Rutledge M; Williams MJA; McCormick SPA; Redpath GMI, 2025, 'Antidepressants stimulate lipoprotein(a) macropinocytosis via serotonin-enhanced cell surface binding', Journal of Lipid Research, 66,

Journal articles | 2025

Kim DH; Boby SE; Redpath GMI; Ananthanarayanan V, 2025, 'Driving cancer: Motor and adaptor protein dysregulation in endocytic receptor signalling', Current Opinion in Cell Biology, 97,

Journal articles | 2024

Tillu VA; Redpath GMI; Rae J; Ruan J; Yao Y; Cagigas ML; Whan R; Hardeman EC; Gunning PW; Ananthanarayanan V; Parton RG; Ariotti N, 2024, 'Precision in situ cryogenic correlative light and electron microscopy of optogenetically positioned organelles', Journal of Cell Science, 137,

Journal articles | 2024

Tirumala NA; Redpath GMI; Skerhut SV; Dolai P; Kapoor-Kaushik N; Ariotti N; Vijay Kumar K; Ananthanarayanan V, 2024, 'Single-molecule imaging of stochastic interactions that drive dynein activation and cargo movement in cells', Journal of Cell Biology, 223,

Journal articles | 2023

Redpath GMI; Ananthanarayanan V, 2023, 'Endosomal sorting sorted 鈥� motors, adaptors and lessons from in vitro and cellular studies', Journal of Cell Science, 136,

Journal articles | 2023

Siddiqui H; Deo N; Rutledge MT; Williams MJA; Redpath GMI; Mccormick SPA, 2023, 'Plasminogen Receptors Promote Lipoprotein(a) Uptake by Enhancing Surface Binding and Facilitating Macropinocytosis', Arteriosclerosis Thrombosis and Vascular Biology, 43, pp. 1851 - 1866,

Journal articles | 2022

Deo N; Redpath G, 2022, 'Serotonin Receptor and Transporter Endocytosis Is an Important Factor in the Cellular Basis of Depression and Anxiety', Frontiers in Cellular Neuroscience, 15,

Journal articles | 2022

Ecker M; Schregle R; Kapoor-Kaushik N; Rossatti P; Betzler VM; Kempe D; Biro M; Ariotti N; Redpath GMI; Rossy J, 2022, 'SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling', Elife, 11,

Journal articles | 2022

Redpath G; Deo N, 2022, 'Serotonin: An overlooked regulator of endocytosis and endosomal sorting?', Biology Open, 11,

Journal articles | 2022

Rossatti P; Redpath GMI; Ziegler L; Samson GPB; Clamagirand CD; Legler DF; Rossy J, 2022, 'Rapid increase in transferrin receptor recycling promotes adhesion during T cell activation', BMC Biology, 20,

Journal articles | 2022

Tirumala NA; Redpath G; Kapoor-Kaushik N; Ariotti N; Dolai P; Kumar KV; Ananthanarayanan V, 2022, 'Single-molecule imaging of cytoplasmic dynein in cellulo reveals the mechanism of motor activation and cargo capture', BIOPHYSICAL JOURNAL, 121, pp. 1 - 1,

Journal articles | 2022

2022, 'Future leader to watch - Gregory Redpath', BIOLOGY OPEN, 11,

Journal articles | 2021

Ecker M; Redpath GMI; Nicovich PR; Rossy J, 2021, 'Quantitative visualization of endocytic trafficking through photoactivation of fluorescent proteins', Molecular Biology of the Cell, 32, pp. 892 - 902,

Journal articles | 2021

Redpath GMI; Deo N; Siddiqui H; Madani G; Kapoor-Kaushik N; Ariotti N; Rutledge M; Williams MJA; McCormick SPA, 2021, 'Serotonin and common antidepressants regulate lipoprotein(a) macropinocytosis via enhanced cell surface binding', ,

Journal articles | 2021

Tirumala NA; Redpath G; Skerhut SV; Dolai P; Kapoor-Kaushik N; Ariotti N; Kumar V; Ananthanarayanan V, 2021, 'Single-molecule imaging of cytoplasmic dynein in cellulo reveals the mechanism of motor activation and cargo movement', ,

Journal articles | 2020

Redpath GMI; Betzler VM; Rossatti P; Rossy J, 2020, 'Membrane Heterogeneity Controls Cellular Endocytic Trafficking', Frontiers in Cell and Developmental Biology, 8,

Journal articles | 2019

Redpath GMI; Ecker M; Kapoor-Kaushik N; Vartoukian H; Carnell M; Kempe D; Biro M; Ariotti N; Rossy J; Kaushik N, 2019, 'Flotillins promote T cell receptor sorting through a fast Rab5鈥揜ab11 endocytic recycling axis', Nature Communications, 10, pp. 4392,

Journal articles | 2018

Compeer EB; Kraus F; Ecker M; Redpath G; Amiezer M; Rother N; Nicovich PR; Kapoor-Kaushik N; Deng Q; Samson GPB; Yang Z; Lou J; Carnell M; Vartoukian H; Gaus K; Rossy J, 2018, 'A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation', Nature Communications, 9,

Journal articles | 2017

Piper AK; Ross SE; Redpath GM; Lemckert FA; Woolger N; Bournazos A; Greer PA; Sutton RB; Cooper ST, 2017, 'Enzymatic cleavage of myoferlin releases a dual C2-domain module linked to ERK signalling', Cellular Signalling, 33, pp. 30 - 40,

Journal articles | 2017

Sharma M; Redpath GM; Williams MJA; McCormick SPA, 2017, 'Recycling of apolipoprotein(a) after PlgRKT-mediated endocytosis of lipoprotein(a)', Circulation Research, 120, pp. 1091 - 1102,

Journal articles | 2016

Redpath GMI; Sophocleous RA; Turnbull L; Whitchurch CB; Cooper ST, 2016, 'Ferlins Show Tissue-Specific Expression and Segregate as Plasma Membrane/Late Endosomal or Trans-Golgi/Recycling Ferlins', Traffic, 17, pp. 245 - 266,

Journal articles | 2016

Sharma M; Redpath G; McCormick S, 2016, 'CALCIUM DEPENDENT ENDOCYTOSIS AND RECYCLING OF LIPOPROTEIN(A) IN HEPG2 CELLS', ATHEROSCLEROSIS, 252, pp. E244 - E244,

Journal articles | 2014

Fuson K; Rice A; Mahling R; Snow A; Nayak K; Shanbhogue P; Meyer AG; Redpath GMI; Hinderliter A; Cooper ST; Sutton RB, 2014, 'Alternate splicing of dysferlin C2A confers Ca2+-dependent and Ca2+-independent binding for membrane repair', Structure, 22, pp. 104 - 115,

Journal articles | 2014

Redpath GMI; Woolger N; Piper AK; Lemckert FA; Lek A; Greer PA; North KN; Cooper ST, 2014, 'Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair', Molecular Biology of the Cell, 25, pp. 3037 - 3048,

Journal articles | 2013

Lek A; Evesson FJ; Lemckert FA; Redpath GMI; Lueders AK; Turnbull L; Whitchurch CB; North KN; Cooper ST, 2013, 'Calpains, cleaved mini-dysferlinc72, and L-type channels underpin calcium-dependent muscle membrane repair', Journal of Neuroscience, 33, pp. 5085 - 5094,
Conference Papers | 2019

Monserrat-Martinez A; Redpath G; Govendir MA; O'Carroll A; Murillo ADA; Sierecki E; Gambin Y, 2019, 'Enteropathogenic E. coli Hijacks Programmed Host-Cell Death Pathways by Interfering with the Higher Order Oligomerization of Immune System Proteins', in FASEB JOURNAL, WILEY, FL, Orlando, presented at Experimental Biology Meeting (EB), FL, Orlando, 06 April 2019 - 09 April 2019

Current:

2026-2028听听听Australian Research Council Discovery Project Grant听听听听听听听听"Uncovering how molecular motors encode receptor signalling".听听听听听听听听听听听听 Dr Vaishnavi Ananthanarayanan, Dr Gregory Redpath (Chief Investigator B), Professor Karsten Kruse. AU$788,064

2025-2028听听 The Health Research Council of New Zealand Project Grant听听听"Uncovering the connection between serotonin and Lp(a) metabolism".听听听听 Professor Sally McCormick, Dr Gregory Redpath听(co-Principal Investigator),听Professor Peter Shepard, Dr Megan Leask, Professor Michael Williams, Professor Paul Glue. NZ$1,050,000

2024-2027听听听Royal Society Te Ap膩rangi Marsden Fund Project Grant听听听听听听听"Unravelling the connection between serotonin and Lp(a) catabolism".听听听听听 Professor Sally McCormick, Dr Gregory Redpath听(co-Principal Investigator). NZ$941,000

2023-2026听听听The Heart Foundation of New Zealand听Project Grant听听听听听听听听听 "Uncovering links between antidepressants and heart disease".听听听听听听听听听 Professor Sally McCormick, Dr Gregory Redpath听(Associate Investigator), Professor Michael Williams. NZ$136,604

2024听听听听听听听School of Biomedical Sciences, 91色情片 Seed Funding Grant听听听听听 "Understanding psychedelics at the molecular level".听听听听听听听听听听听听听听听听听 Dr Gregory Redpath. $AU5,000

2022听听听听听听 听The Lottery Health Foundation of New Zealand Equipment Grant听 "Confocal microscopy for biomedical research".听听听听听听听听听听听听听听听听听听听听听 Professor Sally McCormick, Dr Gregory Redpath, Professor Peter Dearden. NZ$120,000

2022听听听听听听听School of Biomedical Sciences, 91色情片 Seed Funding Grant听听听听听 "Investigating how psychedelics act on serotonin receptors".听听听听听听听听听听听 Dr Gregory Redpath. $AU7,498

2019听听听听听听听University of Otago Research Group Project Grant听听听听听听听听听听听听听"Uncovering how plasminogen receptors control Lp(a) catabolism".听听听听听听听 Professor Sally McCormick,听Dr Gregory Redpath听(Associate Investigator). NZ$63,000

2018-2021听听听Royal Society Te Ap膩rangi Marsden Fund Project Grant听听听听听听听听听 "New players in protein recycling".听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听 Professor Sally McCormick, Dr Torsten Kleffmann,听Dr Gregory Redpath听(Associate Investigator). NZ$957,000

听

2024听听听Shortlisted for the Journal of Cell Science David Stephens Best Paper of the Year Prize

2022 2022	听听 Future Leader to Watch, Biology Open 听听 Featured in Biomedical Picture of the Day, 14 June "Organised Attack"
2018	听听 Runner-up, Best Postdoctoral Presentation, Australia and New Zealand Society for Cell and Development Cell Biology NSW Research Meeting
2014	听听 David Walsh Prize for Best Student Presentation, ComBio 2014
2010	听听 Health Sciences Prestigious Summer Scholarship, University of Otago
2009	听听 Health Research Council Summer Scholarship, Health Research Council of New Zealand

Featured in 91色情片 Newsroom:听/newsroom/news/2025/10/91色情片-research-excellence-recognised-with-35-million-in-ARC-Discovery-funding

Featured in the University of Otago Newsroom:听

My writing for Focal Plane:听

My Research Supervision

Ph.D. Students

Jack Zhang听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听(2023- current)
David Kim听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听(2023- current)
Shreya Boby听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听(2025- current)

听

Previous Supervision

听 Ph.D. Students

Halima Siddiqui听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听(Advisor, University of Otago, NZ, 2019-2023)
Manuela Ecker听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听 (91色情片, 2016-2019)

听 Honours Students

Shreya Boby听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听_听 (2023-2024)
David Kim听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听_听 (2022-2023)
Sarah Skerhut听听 ^听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听 (2022)
Haig Vartoukian听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听(2017)

91色情片

Follow

Dr Gregory Redpath

Follow me