Dr Felix Rizzuto

Scientia Fellow (Level C)

2018-2021 - Banting Postdoctoral Fellow, McGill University
2014-2018 - PhD Chemistry, University of Cambridge��
2008-2014 - BSc(Adv, Hons I)/BA, University of Sydney

Science

School of Chemistry

Dr Felix Rizzuto is a Scientia Senior Lecturer and Moderna Australia Fellow in the School of Chemistry at 91ɫ��Ƭ Sydney. His labs develop��new chemical tools for DNA and RNA nanotechnologies for applications in materials science, therapeutics delivery, biosensing, and nanorobotics.��After receiving his joint BSc/BA from the University of Sydney, he obtained his PhD from the University of Cambridge in 2018. He was then awarded a Banting Postdoctoral Fellowship to work with Prof. Hanadi Sleiman at McGill University in Canada (2018-2021). He started his labs at 91ɫ��Ƭ in 2022 with an ARC DECRA fellowship.

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E-mail

f.rizzuto@unsw.edu.au

Location

Office 746, Hilmer Building E10

Journal articles | 2026

Cox LB; Mattick JS; Middleton IA; Rizzuto FJ; Thordarson P, 2026, 'Specificity of the stabilizing interaction between intrinsically disordered protein sequences and G-quadruplexes in RNA', Nucleic Acids Research, 54,

Journal articles | 2026

Cox LB; Thordarson P; Rizzuto FJ, 2026, 'Peptide-directed folding of the elusive RNA i-motif', Chemical Science,

Journal articles | 2025

Chak MH; Wimberger L; Richardson B; Newman NE; Johansson EMV; Violi JP; Sokolova A; Frisch H; Rizzuto FJ; Donald WA; Stenzel MH; Andréasson J; Beves JE, 2025, 'Photoswitchable Merocyanine-Amphiphiles with Programmable Self-Assembly Times', Chemistry A European Journal, 31,

Journal articles | 2025

Rafique MG; Laurent Q; Dore MD; Fakih HH; Trinh T; Rizzuto FJ; Sleiman HF, 2025, 'Sequence-Defined DNA Polymers: New Tools for DNA Nanotechnology and Nucleic Acid Therapy', Accounts of Chemical Research, 58, pp. 177 - 188,

Journal articles | 2024

Berengut JF; Berg WR; Rizzuto FJ; Lee LK, 2024, 'Passivating Blunt-Ended Helices to Control Monodispersity and Multi-Subunit Assembly of DNA Origami Structures', Small Structures, 5,

Journal articles | 2024

Berengut JF; Berg WR; Rizzuto FJ; Lee LK, 2024, 'Passivating Blunt‐Ended Helices to Control Monodispersity and Multi‐Subunit Assembly of DNA Origami Structures', Small Structures, 5,

Journal articles | 2024

Cox L; Bai C; Platnich CM; Rizzuto FJ, 2024, 'Divergent Polymer Superstructures from Protonated Poly(adenine) DNA and RNA', Biomacromolecules, 25, pp. 3163 - 3168,

Journal articles | 2024

Dore MD; Rafique MG; Yang TP; Zorman M; Platnich CM; Xu P; Trinh T; Rizzuto FJ; Cosa G; Li J; Guarné A; Sleiman HF, 2024, 'Heat-activated growth of metastable and length-defined DNA fibers expands traditional polymer assembly', Nature Communications, 15,

Journal articles | 2023

Berg WR; Berengut JF; Bai C; Wimberger L; Lee LK; Rizzuto FJ, 2023, 'Light-Activated Assembly of DNA Origami into Dissipative Fibrils', Angewandte Chemie International Edition, 62,

Journal articles | 2023

Berg WR; Berengut JF; Bai C; Wimberger L; Lee LK; Rizzuto FJ, 2023, 'Light‐Activated Assembly of DNA Origami into Dissipative Fibrils', Angewandte Chemie, 135,

Journal articles | 2023

Rizzuto FJ; Pal SC; Kearns ER; Hua C; Solomon MB; Doheny PW; Faust TB; Kepert CJ; Das MC; D'Alessandro DM, 2023, 'The physical and electronic properties of Metal-Organic Frameworks containing dipyridylthiazolo[5,4-d]thiazole', Crystengcomm, 25, pp. 6434 - 6440,

Journal articles | 2023

Ryan HP; Fishman ZS; Pawlik JT; Grommet A; Musial M; Rizzuto F; Booth JC; Long CJ; Schwarz K; Orloff ND; Nitschke JR; Stelson AC, 2023, 'Quantifying the Effect of Guest Binding on Host Environment', Journal of the American Chemical Society, 145, pp. 19533 - 19541,

Journal articles | 2023

Saliba D; Luo X; Rizzuto FJ; Sleiman HF, 2023, 'Programming rigidity into size-defined wireframe DNA nanotubes', Nanoscale, 15, pp. 5403 - 5413,

Journal articles | 2023

Wimberger L; Rizzuto FJ; Beves JE, 2023, 'Modulating the Lifetime of DNA Motifs Using Visible Light and Small Molecules', Journal of the American Chemical Society, 145, pp. 2088 - 2092,

Journal articles | 2023

de Rochambeau D; Barłóg M; Rizzuto FJ; Laurent Q; Luo X; Lau KL; Bazzi HS; Sleiman HF, 2023, 'A single monomer difference can impact the nanostructure output of precision oligo(phosphodiesters)', Polymer Chemistry, 14, pp. 3971 - 3977,

Journal articles | 2022

Carpenter JP; Ronson TK; Rizzuto FJ; Héliot T; Grice P; Nitschke JR, 2022, 'Incorporation of a Phosphino(pyridine) Subcomponent Enables the Formation of Cages with Homobimetallic and Heterobimetallic Vertices', Journal of the American Chemical Society, 144, pp. 8467 - 8473,

Journal articles | 2022

Rizzuto FJ; Dore MD; Rafique MG; Luo X; Sleiman HF, 2022, 'DNA Sequence and Length Dictate the Assembly of Nucleic Acid Block Copolymers', Journal of the American Chemical Society, 144, pp. 12272 - 12279,

Journal articles | 2022

Saliba D; Trinh T; Lachance-Brais C; Prinzen AL; Rizzuto FJ; de Rochambeau D; Sleiman HF, 2022, 'Asymmetric patterning drives the folding of a tripodal DNA nanotweezer', Chemical Science, 13, pp. 74 - 80,

Journal articles | 2021

Rizzuto FJ; Platnich CM; Luo X; Shen Y; Dore MD; Lachance-Brais C; Guarné A; Cosa G; Sleiman HF, 2021, 'A dissipative pathway for the structural evolution of DNA fibres', Nature Chemistry, 13, pp. 843 - 849,

Journal articles | 2020

Li Q; Zhao J; Liu L; Jonchhe S; Rizzuto FJ; Mandal S; He H; Wei S; Sleiman HF; Mao H; Mao C, 2020, 'A poly(thymine)–melamine duplex for the assembly of DNA nanomaterials', Nature Materials, 19, pp. 1012 - 1018,

Journal articles | 2020

Plajer AJ; Rizzuto FJ; von Krbek LKS; Gisbert Y; Martínez-Agramunt V; Nitschke JR, 2020, 'Oxidation triggers guest dissociation during reorganization of an FeL6twisted parallelogram', Chemical Science, 11, pp. 10399 - 10404,

Journal articles | 2020

Plajer AJ; Zhu J; Pröhm P; Rizzuto FJ; Keyser UF; Wright DS, 2020, 'Conformational Control in Main Group Phosphazane Anion Receptors and Transporters', Journal of the American Chemical Society, 142, pp. 1029 - 1037,

Journal articles | 2020

Platnich CM; Rizzuto FJ; Cosa G; Sleiman HF, 2020, 'Single-molecule methods in structural DNA nanotechnology', Chemical Society Reviews, 49, pp. 4220 - 4233,

Journal articles | 2020

Rizzuto FJ; Nitschke JR, 2020, 'Narcissistic, integrative, and kinetic self-sorting within a system of coordination cages', Journal of the American Chemical Society, 142, pp. 7749 - 7753,

Journal articles | 2020

Rizzuto FJ; Trinh T; Sleiman HF, 2020, 'Molecular Printing with DNA Nanotechnology', Chem, 6, pp. 1560 - 1574,

Journal articles | 2020

Rousina-Webb A; Lachance-Brais C; Rizzuto FJ; Askari MS; Sleiman HF, 2020, 'Transition-Metal-Functionalized DNA Double-Crossover Tiles: Enhanced Stability and Chirality Transfer to Metal Centers', Advanced Materials, 132, pp. 4120 - 4127,

Journal articles | 2020

Rousina-Webb A; Lachance-Brais C; Rizzuto FJ; Askari MS; Sleiman HF, 2020, 'Transition-Metal-Functionalized DNA Double-Crossover Tiles: Enhanced Stability and Chirality Transfer to Metal Centers', Angewandte Chemie International Edition, 59, pp. 4091 - 4098,

Journal articles | 2019

Askari MS; Lachance-Brais C; Rizzuto FJ; Toader V; Sleiman H, 2019, 'Remote control of charge transport and chiral induction along a DNA-metallohelicate', Nanoscale, 11, pp. 11879 - 11884,

Journal articles | 2019

Plajer AJ; Percástegui EG; Santella M; Rizzuto FJ; Gan Q; Laursen BW; Nitschke JR, 2019, 'Fluorometric Recognition of Nucleotides within a Water-Soluble Tetrahedral Capsule', Angewandte Chemie International Edition, 58, pp. 4200 - 4204,

Journal articles | 2019

Plajer AJ; Percástegui EG; Santella M; Rizzuto FJ; Gan Q; Laursen BW; Nitschke JR, 2019, 'Fluorometric Recognition of Nucleotides within a Water‐Soluble Tetrahedral Capsule', Angewandte Chemie, 131, pp. 4244 - 4248,

Journal articles | 2019

Plajer AJ; Percástegui EG; Santella M; Rizzuto FJ; Gan Q; Laursen BW; Nitschke JR, 2019, 'Innentitelbild: Fluorometric Recognition of Nucleotides within a Water‐Soluble Tetrahedral Capsule (Angew. Chem. 13/2019)', Angewandte Chemie, 131, pp. 4110 - 4110,

Journal articles | 2019

Plajer AJ; Percástegui EG; Santella M; Rizzuto FJ; Gan Q; Laursen BW; Nitschke JR, 2019, 'Inside Cover: Fluorometric Recognition of Nucleotides within a Water‐Soluble Tetrahedral Capsule (Angew. Chem. Int. Ed. 13/2019)', Angewandte Chemie International Edition, 58, pp. 4068 - 4068,

Journal articles | 2019

Plajer AJ; Rizzuto FJ; Niu H; Lee S; Goodman JM; Wright DS, 2019, 'Guest Binding via N−H⋅⋅⋅π Bonding and Kinetic Entrapment by an Inorganic Macrocycle', Angewandte Chemie, 131, pp. 10765 - 10769,

Journal articles | 2019

Plajer AJ; Rizzuto FJ; Niu HC; Lee S; Goodman JM; Wright DS, 2019, 'Guest Binding via N−H⋅⋅⋅π Bonding and Kinetic Entrapment by an Inorganic Macrocycle', Angewandte Chemie International Edition, 58, pp. 10655 - 10659,

Journal articles | 2019

Rizzuto FJ; Carpenter JP; Nitschke JR, 2019, 'Multisite Binding of Drugs and Natural Products in an Entropically Favorable, Heteroleptic Receptor', Journal of the American Chemical Society, 141, pp. 9087 - 9095,

Journal articles | 2019

Rizzuto FJ; Pröhm P; Plajer AJ; Greenfield JL; Nitschke JR, 2019, 'Hydrogen-Bond-Assisted Symmetry Breaking in a Network of Chiral Metal-Organic Assemblies', Journal of the American Chemical Society, 141, pp. 1707 - 1715,

Journal articles | 2019

Rizzuto FJ; von Krbek LKS; Nitschke JR, 2019, 'Strategies for binding multiple guests in metal–organic cages', Nature Reviews Chemistry, 3, pp. 204 - 222,

Journal articles | 2018

Plajer AJ; Colebatch AL; Rizzuto FJ; Pröhm P; Bond AD; García-Rodríguez R; Wright DS, 2018, 'How Changing the Bridgehead Can Affect the Properties of Tripodal Ligands', Angewandte Chemie International Edition, 57, pp. 6648 - 6652,

Journal articles | 2018

Plajer AJ; Colebatch AL; Rizzuto FJ; Pröhm P; Bond AD; García‐Rodríguez R; Wright DS, 2018, 'How Changing the Bridgehead Can Affect the Properties of Tripodal Ligands', Angewandte Chemie, 130, pp. 6758 - 6762,

Journal articles | 2018

Plajer AJ; Garcia-Rodriguez R; Rizzuto FJ; Wright DS, 2018, 'Flexible Bonding of the Phosph(V)azane Dianions [S(E)P(μ-NtBu)]2 2−', Chemistry A European Journal, 24, pp. 2013 - 2019,

Journal articles | 2018

Plajer AJ; Niu HC; Rizzuto FJ; Wright DS, 2018, 'Formation and selection of the macrocycle [{(: TBuN)P(μ-NtBu)}2(μ-Se)2{P(μ-NtBu)}2]3', Dalton Transactions, 47, pp. 6675 - 6678,

Journal articles | 2018

Rizzuto FJ; Kieffer M; Nitschke JR, 2018, 'Quantified structural speciation in self-sorted Co II 6 L4 cage systems', Chemical Science, 9, pp. 1925 - 1930,

Journal articles | 2018

Rizzuto FJ; Ramsay WJ; Nitschke JR, 2018, 'Otherwise Unstable Structures Self-Assemble in the Cavities of Cuboctahedral Coordination Cages', Journal of the American Chemical Society, 140, pp. 11502 - 11509,

Journal articles | 2017

Greenfield JL; Rizzuto FJ; Goldberga I; Nitschke JR, 2017, 'Self-Assembly of Conjugated Metallopolymers with Tunable Length and Controlled Regiochemistry', Angewandte Chemie International Edition, 56, pp. 7541 - 7545,

Journal articles | 2017

Greenfield JL; Rizzuto FJ; Goldberga I; Nitschke JR, 2017, 'Self‐Assembly of Conjugated Metallopolymers with Tunable Length and Controlled Regiochemistry', Angewandte Chemie, 129, pp. 7649 - 7653,

Journal articles | 2017

Plajer AJ; Bold K; Rizzuto FJ; García-Rodríguez R; Ronson TK; Wright DS, 2017, 'Isomerisation, reactivity and coordination chemistry of a new hybrid, multi-functional phosphazane', Dalton Transactions, 46, pp. 12775 - 12779,

Journal articles | 2017

Rizzuto FJ; Nitschke JR, 2017, 'Stereochemical plasticity modulates cooperative binding in a CoII12L6 cuboctahedron', Nature Chemistry, 9, pp. 903 - 908,

Journal articles | 2017

Rizzuto FJ; Wood DM; Ronson TK; Nitschke JR, 2017, 'Tuning the Redox Properties of Fullerene Clusters within a Metal-Organic Capsule', Journal of the American Chemical Society, 139, pp. 11008 - 11011,

Journal articles | 2016

Hua C; Rizzuto FJ; Zhang X; Tuna F; Collison D; D'Alessandro DM, 2016, 'Spectroelectrochemical properties of a Ru(ii) complex with a thiazolo[5,4-d]thiazole triarylamine ligand', New Journal of Chemistry, 41, pp. 108 - 114,

Journal articles | 2016

Ramsay WJ; Rizzuto FJ; Ronson TK; Caprice K; Nitschke JR, 2016, 'Subtle Ligand Modification Inverts Guest Binding Hierarchy in MII8L6 Supramolecular Cubes', Journal of the American Chemical Society, 138, pp. 7264 - 7267,

Journal articles | 2016

Rizzuto FJ; Wu W; Ronson TK; Nitschke JR, 2016, 'Innentitelbild: Peripheral Templation Generates an M^II₆L₄ Guest‐Binding Capsule (Angew. Chem. 28/2016)', Angewandte Chemie, 128, pp. 7996 - 7996,

Journal articles | 2016

Rizzuto FJ; Wu W; Ronson TK; Nitschke JR, 2016, 'Peripheral Templation Generates an M^II₆L₄ Guest‐Binding Capsule', Angewandte Chemie, 128, pp. 8090 - 8094,

Journal articles | 2016

Rizzuto FJ; Wu WY; Ronson TK; Nitschke JR, 2016, 'Inside Cover: Peripheral Templation Generates an MII6L4Guest-Binding Capsule (Angew. Chem. Int. Ed. 28/2016)', Angewandte Chemie International Edition, 55, pp. 7866,

Journal articles | 2016

Rizzuto FJ; Wu WY; Ronson TK; Nitschke JR, 2016, 'Peripheral Templation Generates an MII6L4Guest-Binding Capsule', Angewandte Chemie International Edition, 55, pp. 7958 - 7962,

Journal articles | 2015

Rizzuto FJ; Hua C; Chan B; Faust TB; Rawal A; Leong CF; Hook JM; Kepert CJ; D'Alessandro DM, 2015, 'The electronic, optical and magnetic consequences of delocalization in multifunctional donor-acceptor organic polymers', Physical Chemistry Chemical Physics, 17, pp. 11252 - 11259,

Journal articles | 2014

Murphy MJ; Usov PM; Rizzuto FJ; Kepert CJ; D'Alessandro DM, 2014, 'Magnetic, electrochemical and optical properties of a sulfate-bridged Co(ii) imidazole dimer', New Journal of Chemistry, 38, pp. 5856 - 5860,

Journal articles | 2014

Rizzuto FJ; Faust TB; Chan B; Hua C; D'Alessandro DM; Kepert CJ, 2014, 'Experimental and computational studies of a multi-electron donor-acceptor ligand containing the thiazolo[5,4-d]thiazole core and its incorporation into a metal-organic framework', Chemistry A European Journal, 20, pp. 17597 - 17605,
Preprints | 2026

Cox L; Thordarson P; Rizzuto F, 2026, Peptide-Directed Folding of the Elusive RNA i-Motif,

Preprints | 2026

Uehara DA; Khazid YH; Berg WR; Rizzuto FJ, 2026, Intrinsic pH-driven actuation of DNA origami rectangles,

Preprints | 2025

Chak MH; Wimberger L; Richardson B; Newman N; Johansson EMV; Violi JP; Sokolova A; Frisch H; Rizzuto F; Donald WA; Stenzel MH; Andréasson J; Beves J, 2025, Photoswitchable merocyanine-amphiphiles with programmable self-assembly times,

Preprints | 2025

Cox L; Mattick J; Middleton I; Rizzuto F; Thordarson P, 2025, Specificity of the stabilising interaction between intrinsically disordered protein sequences and G-quadruplexes in RNA,

Preprints | 2023

Berengut JF; Berg WR; Rizzuto FJ; Lee LK, 2023, Passivating blunt-ended helices to control monodispersity and multi-subunit assembly of DNA origami structures,

Preprints | 2022

Luo X; Zhu J; Rizzuto F; Lennox RB; Sleiman H, 2022, Programmed ripening of nanoparticles using a DNA template,

Preprints | 2022

Luo X; Zhu J; Rizzuto F; Lennox RB; Sleiman H, 2022, Programmed ripening of nanoparticles using a DNA template,

Preprints | 2022

Rizzuto F; Dore M; Rafique MG; Luo X; Sleiman H, 2022, DNA Sequence and Length Dictate the Assembly of Nucleic Acid Block Copolymers,

Preprints | 2022

Wimberger L; Rizzuto F; Beves J, 2022, Modulating the lifetime of DNA motifs using visible light and small molecules,

Preprints | 2022

Wimberger L; Rizzuto F; Beves J, 2022, Modulating the lifetime of DNA motifs using visible light and small molecules,

Discovery Project (2025-2028) - F. Rizzuto, J. Beves, P. Wich, Lights, DNA, action! Photo-controlled machinery for nanorobotics.

Discovery Project (2025-2028) - F. Rizzuto, A. Wang, L. Lee, P. Thordarson, Modular nanopores as conduits for nanoreactors.

Moderna Australia Fellowship (2025-2027) - F. Rizzuto, Pulling a Houdini with DNA origami.

Discovery Early Career Research Award (DECRA) (2022-2025), F. Rizzuto,��Biomimetic catalysis for sustainable polymer syntheses.

2025 - Early Career Researcher of the Year (Physical Sciences): Premier's Prize for Science and Engineering
2025 - NSW Young Tall Poppy
2025 - 91ɫ��Ƭ Scientia Fellowship
2021 -��Relève étoile Louis-Berlinguet du Fonds de recherche du Québec – Nature et technologies
2019 - 'Gadolinium' on��IUPAC Periodic Table of Younger Chemists��
2018 - Banting Postdoctoral Research Fellowship
2015 -��Scifinder Future Leaders in Chemistry Program

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