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Dr Alexander Underwood

Dr Alexander Underwood

Post-Doc Fellow
Medicine & Health
Pathology

Alex has successfully completed a B.Sc (Hons) majoring in medical microbiology and immunology in 2015 at 91色情片, Sydney. He finished with first class honours and published his first research paper in 2016 summerising his work on听Campylobacter concisus pathotypes in gastroenteritis. In the same year, Alex started his PhD with VISP moving his research to HCV. He now specialises in B cell analyses, specifically broad neutralising antibodies and their importance for vaccine development in HCV.听

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Qualifications

B.Sc (Hons) 91色情片, 2016.

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E-mail
a.underwood@unsw.edu.au
  • Journal articles | 2025
    Apol 脕D; S酶lund C; Vinten C; Underwood AP; Bukh J; Weis N, 2025, 'Cure of chronic hepatitis C virus infection after DAA treatment only partially restores the functional capacity of exhausted T cell subsets: a systematic review', Frontiers in Immunology, 16,
    Journal articles | 2025
    Dalegaard MI; Winckelmann A; Fahn酶e U; Underwood AP; Pedersen AG; Bollerup S; Bukh J; Weis N, 2025, 'Higher Rates of Viral Evolution in Chronic Hepatitis B Patients Linked to Predicted T Cell Epitopes', Viruses, 17,
    Journal articles | 2025
    Fahn酶e U; Feng S; Underwood AP; Jacobsen K; Ameri A; Blicher TH; S酶lund CS; Rosenberg BR; Brix L; Weis N; Bukh J, 2025, 'T cell receptor usage and epitope specificity amongst CD8+ and CD4+ SARS-CoV-2-specific T cells', Frontiers in Immunology, 16,
    Journal articles | 2025
    Vizgirda G; Underwood AP; Fahn酶e U; Weis N; Ramirez S; Bukh J, 2025, 'Spike substitutions E484D, P812R and Q954H mediate ACE2-independent entry of SARS-CoV-2 across different cell lines', Plos One, 20,
    Journal articles | 2024
    Offersgaard A; Duarte Hernandez CR; Zhou Y; Duan Z; Gammeltoft KA; Hartmann KT; Fahn酶e U; Marichal-Gallardo P; Alzua GP; Underwood AP; S酶lund C; Weis N; Bonde JH; Christensen JP; Pedersen GK; Jensen HE; Holmbeck K; Bukh J; Gottwein JM, 2024, 'An inactivated SARS-CoV-2 vaccine based on a Vero cell culture-adapted high-titer virus confers cross-protection in small animals', Scientific Reports, 14,
    Journal articles | 2024
    Pham LV; Underwood AP; Binderup A; Fahn酶e U; Fernandez-Antunez C; Lopez-Mendez B; Ryberg LA; Galli A; S酶lund C; Weis N; Ramirez S; Bukh J, 2024, 'Neutralisation resistance of SARS-CoV-2 spike-variants is primarily mediated by synergistic receptor binding domain substitutions', Emerging Microbes and Infections, 13,
    Journal articles | 2024
    Underwood AP; Gupta M; Wu BR; Eltahla AA; Boo I; Wang JJ; Agapiou D; Abayasingam A; Reynaldi A; Keoshkerian E; Zhao Y; Brasher N; Walker MR; Bukh J; Maher L; Gordon T; Davenport MP; Luciani F; Drummer HE; Lloyd AR; Bull RA, 2024, 'B-cell characteristics define HCV reinfection outcome', Journal of Hepatology, 81, pp. 415 - 428,
    Journal articles | 2024
    Underwood AP; S酶lund C; Jacobsen K; Binderup A; Fernandez-Antunez C; Mikkelsen LS; Inekci D; Villadsen SL; Castruita JAS; Pinholt M; Fahn酶e U; Ramirez S; Brix L; Weis N; Bukh J, 2024, 'Neutralizing antibody and CD8+ T cell responses following BA.4/5 bivalent COVID-19 booster vaccination in adults with and without prior exposure to SARS-CoV-2', Frontiers in Immunology, 15,
    Journal articles | 2024
    Walker MR; Underwood A; Bj枚rnsson KH; Raghavan SSR; Bassi MR; Binderup A; Pham LV; Ramirez S; Pinholt M; Dagil R; Knudsen AS; Idorn M; Soegaard M; Wang K; Ward AB; Salanti A; Bukh J; Barfod L, 2024, 'Broadly potent spike-specific human monoclonal antibodies inhibit SARS-CoV-2 Omicron sub-lineages', Communications Biology, 7,
    Journal articles | 2023
    Smit MJ; Sander AF; Ariaans MBPA; Fougeroux C; Heinzel C; Fendel R; Esen M; Kremsner PG; ter Heine R; Wertheim HF; Idorn M; Paludan SR; Underwood AP; Binderup A; Ramirez S; Bukh J; Soegaard M; Erdogan SM; Gustavsson T; Clemmensen S; Theander TG; Salanti A; Hamborg M; de Jongh WA; McCall MBB; Nielsen MA; Mordm眉ller BG; Riis Paludan S; Dagil R; Goks酶yr L; Hulen TM; Janitzek C; Jensen DS; Justesen S; Khalif茅 PK; Kreidenweiss A; Lan莽a T; Lie-Andersen O; Teelen K; Vidal-Calvo E, 2023, 'First-in-human use of a modular capsid virus-like vaccine platform: an open-label, non-randomised, phase 1 clinical trial of the SARS-CoV-2 vaccine ABNCoV2', Lancet Microbe, 4, pp. e140 - e148,
    Journal articles | 2023
    Underwood AP; Gupta M; Wu B-R; Eltahla AA; Boo I; Wang JJ; Agapiou D; Abayasingam A; Reynaldi A; Keoshkerian E; Zhao Y; Brasher N; Walker MR; Bukh J; Maher L; Gordon T; Davenport M; Luciani F; Drummer HE; Lloyd AR; Bull RA, 2023, 'B Cell Signatures and Antibody Imprinting Define HCV Reinfection Outcome', ,
    Journal articles | 2023
    Underwood AP; S酶lund C; Fernandez-Antunez C; Villadsen SL; Mikkelsen LS; Fahn酶e U; Bollerup S; Winckelmann AA; Schneider UV; Binderup A; Vizgirda G; S酶rensen AL; Vinten CN; Dalegaard MI; Ramirez S; Weis N; Bukh J, 2023, 'Durability and breadth of neutralisation following multiple antigen exposures to SARS-CoV-2 infection and/or COVID-19 vaccination', Ebiomedicine, 89,
    Journal articles | 2022
    Fahn酶e U; Ronit A; Berg RMG; J酶rgensen SE; Mogensen TH; Underwood AP; Scheel TKH; Bukh J; Plovsing RR, 2022, 'A Distinct Dexamethasone-Dependent Gene Expression Profile in the Lungs of COVID-19 Patients', Journal of Infectious Diseases, 226, pp. 2137 - 2141,
    Journal articles | 2022
    S酶lund C; Underwood AP; Fernandez-Antunez C; Bollerup S; Mikkelsen LS; Villadsen SL; Fahn酶e U; Winckelmann AA; Feng S; N酶rl酶v Vinten CA; Dalegaard MI; Vizgirda G; S酶rensen AL; Ramirez S; Bukh J; Weis N, 2022, 'Analysis of Neutralization Titers against SARS-CoV-2 in Health-Care Workers Vaccinated with Prime-Boost mRNA鈥搈RNA or Vector鈥搈RNA COVID-19 Vaccines', Vaccines, 10,
    Journal articles | 2021
    Kalemera MD; Capella-Pujol J; Chumbe A; Underwood A; Bull RA; Schinkel J; Sliepen K; Grove J, 2021, 'Optimized cell systems for the investigation of hepatitis C virus E1E2 glycoproteins', Journal of General Virology, 102,
    Journal articles | 2021
    Lassauni猫re R; Fonager J; Rasmussen M; Frische A; Polacek C; Rasmussen TB; Lohse L; Belsham GJ; Underwood A; Winckelmann AA; Bollerup S; Bukh J; Weis N; S忙kmose SG; Aagaard B; Alfaro-N煤帽ez A; M酶lbak K; B酶tner A; Fomsgaard A, 2021, 'In vitro Characterization of Fitness and Convalescent Antibody Neutralization of SARS-CoV-2 Cluster 5 Variant Emerging in Mink at Danish Farms', Frontiers in Microbiology, 12,
    Journal articles | 2021
    Ramirez S; Fernandez-Antunez C; Galli A; Underwood A; Pham LV; Ryberg LA; Feng S; Pedersen MS; Mikkelsen LS; Belouzard S; Dubuisson J; S酶lund C; Weis N; Gottwein JM; Fahn酶e U; Bukh J, 2021, 'Overcoming culture restriction for SARS-CoV-2 in human cells facilitates the screening of compounds inhibiting viral replication', Antimicrobial Agents and Chemotherapy, 65,
    Journal articles | 2021
    Underwood AP; S酶lund C; Fernandez-Antunez C; Villadsen SL; Winckelmann AA; Bollerup S; Mikkelsen LS; S酶rensen AL; Feng S; Fahn酶e U; Lassauniere R; Fomsgaard A; Ramirez S; Weis N; Bukh J, 2021, 'Neutralisation titres against SARS-CoV-2 are sustained 6 months after onset of symptoms in individuals with mild COVID-19', Ebiomedicine, 71,
    Journal articles | 2020
    Brasher NA; Eltahla AA; Underwood A; Boo I; Rizzetto S; Walker MR; Rodrigo C; Luciani F; Maher L; Drummer HE; Tedla N; Lloyd AR; Bull RA, 2020, 'B cell immunodominance in primary hepatitis C virus infection', Journal of Hepatology, 72, pp. 670 - 679,
    Journal articles | 2020
    Mina M; Underwood A; Eltahla A; Wu BR; Walker MR; Bull RA; Lloyd AR, 2020, 'Anti-envelope antibody responses in highly exposed seronegative individuals may be associated with protection from HCV infection', Journal of Viral Hepatitis, 27, pp. 1012 - 1021,
    Journal articles | 2019
    Keck ZY; Pierce BG; Lau P; Lu J; Wang Y; Underwood A; Bull RA; Prentoe J; Vel谩zquez-Moctezuma R; Walker MR; Luciani F; Guest JD; Fauvelle C; Baumert TF; Bukh J; Lloyd AR; Foung SKH, 2019, 'Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis c virus infections uncover molecular determinants for E2 targeting and vaccine design', Plos Pathogens, 15, pp. e1007772,
    Journal articles | 2019
    Masavuli MG; Wijesundara DK; Underwood A; Christiansen D; Earnest-Silveira L; Bull R; Torresi J; Gowans EJ; Grubor-Bauk B, 2019, 'A hepatitis C virus DNA vaccine encoding a secreted, oligomerized form of envelope proteins is highly immunogenic and elicits neutralizing antibodies in vaccinated mice', Frontiers in Immunology, 10,
    Journal articles | 2019
    Walker MR; Leung P; Eltahla AA; Underwood A; Abayasingam A; Brasher NA; Li H; Wu BR; Maher L; Luciani F; Lloyd AR; Bull RA, 2019, 'Clearance of hepatitis C virus is associated with early and potent but narrowly-directed, Envelope-specific antibodies', Scientific Reports, 9, pp. 13300,
    Journal articles | 2019
    Wu BR; Eltahla AA; Keoshkerian E; Walker MR; Underwood A; Brasher NA; Agapiou D; Lloyd AR; Bull RA, 2019, 'A method for detecting hepatitis C envelope specific memory B cells from multiple genotypes using cocktail E2 tetramers', Journal of Immunological Methods, 472, pp. 65 - 74,
    Journal articles | 2018
    Casta帽o-Rodr铆guez N; Underwood AP; Merif J; Riordan SM; Rawlinson WD; Mitchell HM; Kaakoush NO, 2018, 'Gut microbiome analysis identifies potential etiological factors in acute gastroenteritis', Infection and Immunity, 86, pp. 10.1128/iai.00060 - 10.1128/iai.00018,
    Journal articles | 2018
    Underwood AP; Walker MR; Brasher NA; Eltahla AA; Maher L; Luciani F; Lloyd AR; Bull RA, 2018, 'Understanding the determinants of BnAb induction in acute HCV infection', Viruses, 10, pp. 659,
    Journal articles | 2016
    Underwood AP; Kaakoush NO; Sodhi N; Merif J; Lee WS; Riordan SM; Rawlinson WD; Mitchell HM, 2016, 'Campylobacter concisus pathotypes are present at significant levels in patients with gastroenteritis', Journal of Medical Microbiology, 65, pp. 219 - 226,
  • Preprints | 2023
    Walker M; Underwood A; Raghavan SSR; Bassi M; Bj枚rnsson K; Binderup A; Pham L; Ramirez S; Pinholt M; Dagil R; Knudsen A; Idorn M; S酶gaard M; Wang K; Salanti A; Bukh J; Barfod L, 2023, Novel, broad and potent spike-specific human monoclonal antibodies inhibit SARS-CoV-2 Omicron sub-lineages,
    Preprints | 2022
    Fahn酶e U; Ronit A; Berg RMG; J酶rgensen SE; Mogensen TH; Underwood AP; Scheel TKH; Bukh J; Plovsing RR, 2022, A unique dexamethasone-dependent gene expression profile in the lungs of COVID-19 patients,
    Preprints | 2020
    Kalemera M; Cappella-Pujol J; Chumbe A; Underwood A; Bull R; Schinkel J; Sliepen K; Grove J, 2020, Optimised cell systems for the investigation of hepatitis C virus E1E2 glycoproteins,