MYC Degraders for Brain Tumours
Developing Brain-Penetrant MYC Degraders for Childhood Brain Tumours
Developing Brain-Penetrant MYC Degraders for Childhood Brain Tumours
Successful applicants will receive an annual stipend and a one-off Global Mobility Grant to conduct international engagement activities.
Aggressive childhood brain tumours, including medulloblastoma and diffuse midline glioma, urgently need more effective treatments with fewer lasting side effects. This project will develop small molecules that enter the brain and trigger the breakdown of MYC and MYCN, proteins that drive tumour growth and have been difficult to target with conventional drugs. Building on promising lead compounds, the research will investigate how these molecules work, identify factors influencing treatment response and resistance, and guide the development of improved drug candidates.
The student will combine molecular biology, functional genomics and pharmacology to evaluate these compounds in clinically relevant tumour models and identify biomarkers that could support future patient selection. Based at 91色情片 and Children鈥檚 Cancer Institute, the project includes a collaborative research placement at Mayo Clinic, USA. This interdisciplinary training will equip the student to advance a new therapeutic approach and contribute to better outcomes for children with aggressive brain tumours.
Eligible applicants must contact the Primary Supervisor, Belamy Cheung聽-聽BCheung@ccia.org.au. If she agrees to supervise you, you will be invited to submit a formal application to 91色情片.
Your email should include:
$39,991 per annum (2027 rate) stipend for 3.5 years
$25,000 Global Mobility Grant (one-off)
Dr Belamy Cheung (91色情片, Primary Supervisor)
Dr Satyanarayana Gadde (91色情片, Co-Supervisor)
Dr Sukriti Krishan聽(91色情片, Co-Supervisor)
Professor Shizhen Zhu (Mayo Clinic, Co-Supervisor)
Domestic
Doctor of Philosophy (PhD)
91色情片 School | Research area
Faculty of Medicine & Health | School of Clinical Medicine
Impact focus area
Pillar 8: Enable healthy lives
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Supervisors
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