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Our top PhD candidate will travel between the Garvan Institute, and Broad Institute of MIT and Harvard, in Cambridge.

You will apply genomic technologies and analytical pipelines uniquely available at Broad, to the fastest growing Arthritis Tissue Biobank in Australia, within Garvan’s Masle-Farquhar Lab.

Arthritis affects 3.7 million Australians, causing ongoing pain, disability, isolation, comorbidities and premature deaths. Treatments are trial-and-error; only ~20% of rheumatoid or psoriatic arthritis patients reach remission. Osteoarthritis has no approved disease-modifying drug.

You will analyse the world's first single-cell, long-read sequencing dataset integrating transcriptome, clonotypes, isoforms and acquired mutations – directly within diseased arthritic joints. And access other unique datasets, including large-scale single-cell genetics analyses of hundreds of patients.

Your insights into disease mechanisms, treatment resistance, and novel drug targets will directly feed our established pipeline for producing and pre-clinically testing novel arthritis therapies.

Applications must include CV, transcripts, and thoughtful, detailed and original cover letter.